Category: Cardiometabolic Health & Metabolism

XanthiTrim supports healthy weight management† when combined with a healthy diet and exercise. XanthiTrim contains 300 mg of Xanthigen per serving, a synergistic combination of fucoxanthin from brown seaweed and pomegranate seed oil. In a 16-week, randomized study, Xanthigen supported healthy weight management† and fat metabolism in volunteers. This was attributed in part to its ability to encourage resting energy expenditure and thermogenesis, the body’s natural ability to dissipate caloric energy as heat from the mitochondria of adipose tissue. This results in oxidation and utilization of fats rather than fat storage. In this study, Xanthigen also maintained healthy liver fat metabolism and function, and healthy lipid metabolism. Subjects were on a moderately calorie-restricted diet. GreenSelect Phytosome is a proprietary, caffeine-free extract from green tea, that is 1 part GreenSelect green tea to 2 parts phosphatidylcholine. This allows for greater absorption of epigallocatechin gallate, or EGCG, one of the primary components known to support healthy metabolism. Green tea has demonstrated the ability to promote resting energy expenditure and thermogenesis in a number of clinical studies. A 90-day study involving GreenSelect Phytosome revealed its ability to support healthy weight management† and body composition in subjects following a calorie-restricted diet.

†Provides weight management support as part of a healthy lifestyle with a reduced calorie diet and regular exercise.

Ubiquinol is the active antioxidant form of CoQ10. It has an additional two hydrogen atoms and comprises the majority of the ubiquinone/ubiquinol pool in the plasma of healthy subjects. Ubiquinol may be especially important for older individuals, individuals who may be experiencing greater levels of oxidative or physical stress, or for individuals who appear not to respond to regular CoQ10 supplementation (possibly due to poor conversion of CoQ10 to ubiquinol in the body). Research suggests that it may be more readily absorbed than ubiquinone. In a comparison study involving healthy subjects, supplementation with 200 mg ubiquinol for 4 weeks increased plasma total CoQ10 from 0.9 to 4.3 μg/mL (P 10 to lipids. Research indicates ubiquinol supports antioxidant status, healthy ejection fraction and mitral valve function while supporting overall physical activity and quality of life. The safety and bioavailability of ubiquinol were evaluated after single oral dose and 4-week multiple dose studies. Significant gastrointestinal absorption was observed and no clinically significant adverse effects were noted.

Magnesium supports healthy cellular electrolyte function and vascular smooth muscle cells. The importance of magnesium intake was demonstrated in the 10 year follow-up of the Women’s Health Study, where higher intakes of dietary magnesium were associated with maintaining healthy vascular relaxation. Both hawthorn and olive leaf have a long history of traditional use for maintaining cardiovascular health and have supported vascular function in studies. Patent pending MegaNatural-BP supports healthy blood vessel relaxation in volunteers, as demonstrated in a study conducted at the University of California, Davis. MegaNatural-BP grape seed is unique in that the extraction process maximizes the concentration of monomeric and oligomeric procyanidins and minimizes the concentration of polymeric procyanidins. Pomegranate, standardized to contain 40% punicosides, offers the antioxidant and vascular benefits associated with pomegranate juice. CranLoad delivers a unique cranberry and grape seed blend developed as part of an extensive research program with the Institute of Nutrition and Functional Foods (INAF) and UniversitÇ Laval in Quebec, Canada. In addition to possessing antioxidant activity, these compounds offer specific vascular support mechanisms that are associated with enhanced endothelial function. In a pilot trial involving elite athletes, CranLoad provided statistically significant support for healthy flow-mediated dilation (FMD) at rest, an effect similar to arginine administration.

Ubiquinol is the active antioxidant form of CoQ10. It has an additional two hydrogen atoms and comprises the majority of the ubiquinone/ubiquinol pool in the plasma of healthy subjects. Ubiquinol may be especially important for older individuals, individuals who may be experiencing greater levels of oxidative or physical stress, or for individuals who appear not to respond to regular CoQ10 supplementation (possibly due to poor conversion of CoQ10 to ubiquinol in the body). Research suggests that it may be more readily absorbed than ubiquinone. In a comparison study involving healthy subjects, supplementation with 200 mg ubiquinol for 4 weeks increased plasma total CoQ10 from 0.9 to 4.3 μg/mL (P 10 to lipids. Research indicates ubiquinol supports antioxidant status, healthy ejection fraction and mitral valve function while supporting overall physical activity and quality of life. The safety and bioavailability of ubiquinol were evaluated after single oral dose and 4-week multiple dose studies. Significant gastrointestinal absorption was observed and no clinically significant adverse effects were noted.‡

Sodium R-alpha-lipoic acid is a highly bioavailable and stabilized form of R-lipoic acid. Regular R-lipoic acid is heat sensitive and may polymerize extensively, decreasing its absorption significantly. In real-time stability tests, sodium R-lipoic acid remained stable for 12 months. The natural R isomer of alpha-lipoic acid may provide enhanced antioxidant activity, energy production, and general metabolic function. Studies suggest that R-lipoic acid offers support for glucose metabolism in skeletal muscle. A University of California Berkeley study indicates that R-lipoic acid may be protective against age-related oxidative stress in the liver. Furthermore, a study at Oregon State University established a potential role for R-lipoic acid in protecting the heart from age-related oxidative stress.

Sodium R-alpha-lipoic acid is a highly bioavailable and stabilized form of R-lipoic acid. Regular R-lipoic acid is heat sensitive and may polymerize extensively, decreasing its absorption significantly. In real-time stability tests, sodium R-lipoic acid remained stable for 12 months. The natural R isomer of alpha-lipoic acid may provide enhanced antioxidant activity, energy production, and general metabolic function. Studies suggest that R-lipoic acid offers support for glucose metabolism in skeletal muscle. A University of California Berkeley study indicates that R-lipoic acid may be protective against age-related oxidative stress in the liver. Furthermore, a study at Oregon State University established a potential role for R-lipoic acid in protecting the heart from age-related oxidative stress.

PQQ and CoQ10 promote antioxidant activity and mitochondrial health through different mechanisms, providing multifunctional support for cardiovascular health and neuroprotection. PQQ promotes cardiovascular health by supporting heart muscle function, cellular oxygen utilization and protecting cell membranes from oxidative stress. PQQ maintains neural health by supporting nerve growth factor (NGF) and supporting synaptic and intracellular neuronal responses by maintaining healthy N-methyl D-aspartate (NMDA) receptor activity. The NMDA receptor is the primary conduit for excitatory glutamate neurotransmission and is regarded as an important target for maintaining neuronal health. Mechanistic investigations suggest that PQQ supports several signal transduction pathways that are important in maintaining mitochondrial homeostasis and oxidative metabolism. Recent studies show that PQQ supports mental processing. In a double-blind, placebo-controlled clinical trial conducted in 71 middle-aged individuals, BioPQQ supplementation over a 12 week period supported healthy cognitive performance, specifically high-end mental processing. CoQ10 provides cardiovascular, cognitive and antioxidant support to complement the activity of PQQ. It is offered in this formula as water-soluble, enhanced-absorption, sustained-release MicroActive CoQ10. The patented production process results in CoQ10 with superior absorption compared to solubilized and crystalline CoQ10. What is PQQ?
• PQQ (pyrroloquinoline quinone) is a novel cofactor with antioxidant and B vitamin-like activity
• PQQ is a unique neuroprotectant and cardioprotectant
• PQQ is naturally present in vegetables and in the human body, including breast milk
• BioPQQ is manufactured in Japan using a patented natural fermentation processWhat are the benefits of PQQ?
• PQQ promotes cardiovascular health by supporting heart muscle function, cellular oxygen utilization and protecting cell membranes from oxidative stress
• PQQ maintains neural health by supporting nerve growth factor (NGF), neuronal receptor activity and molecular signals that promote mitochondrial function
• Recent studies show that PQQ supports mental processingWhat are the features of SR-CoQ10?
• A water-soluble, nanosized CoQ10 generated using a patented process
• Clinically studied to show superior absorption compared to solubilized and crystalline CoQ10, with low inter-subject variance
• 24-hour sustained release prolongs plasma CoQ10 levels and allows for convenient once-daily dosing
• Provides cardiovascular, cognitive and antioxidant support to complement the activity of PQQSR-CoQ10 with PQQ: A powerful combination for cardiac, neural and cognitive healthPQQ and CoQ10 promote antioxidant activity and mitochondrial health through different mechanisms, providing multifunctional support for cardiovascular health and neuroprotection. In a double-blind, placebo-controlled clinical trial conducted in 71 middle-aged individuals, BioPQQ supplementation over a 12 week period supported healthy cognitive performance, specifically high-end mental processing.Pure Encapsulations: A PQQ PioneerPQQ was first discovered in 1979. Since its discovery, scientists have discovered the many facets of cardioprotection and neuroprotection afforded by PQQ. In 1987, Japanese-based Mitsubishi initiated production of PQQ in limited quantities for research purposes. The launch of BioPQQ is a milestone after decades of research and effort to commercialize PQQ.

Taurine is the most abundant free amino acid in the brain, heart, and nervous system, and it plays a role in the healthy functioning of the brain, heart, gallbladder, eyes, and vascular system. It facilitates the passage of sodium, potassium, and, possibly, calcium and magnesium ions into and out of cells, and electrically stabilizes cell membranes. It maintains healthy cAMP activity, which activates important enzymes in the heart muscle, and contributes to the muscle’s contractibility. Taurine is an important component of bile acids which aid in the absorption of fat-soluble vitamins. It aids the body’s chemistry to support the normal detoxification process. Dietary taurine promotes the formation of taurocholate, a substance which increases cholesterol secretion in the bile and also supports fat metabolism in the liver.‡

Taurine is the most abundant free amino acid in the brain, heart, and nervous system, and it plays a role in the healthy functioning of the brain, heart, gallbladder, eyes, and vascular system. It facilitates the passage of sodium, potassium, and, possibly, calcium and magnesium ions into and out of cells, and electrically stabilizes cell membranes. It maintains healthy cAMP activity, which activates important enzymes in the heart muscle, and contributes to the muscle’s contractibility. Taurine is an important component of bile acids which aid in the absorption of fat-soluble vitamins. It aids the body’s chemistry to support the normal detoxification process. Dietary taurine promotes the formation of taurocholate, a substance which increases cholesterol secretion in the bile and also supports fat metabolism in the liver.

Active antioxidant form of CoQ10; self-assembling nano-colloid system for enhanced ubiquinol absorption
• A cross-over, pharmacokinetic pilot study (single oral dose) in humans compared an oil-based CoQ10 preparation to CoQ10 in the VESIsorb delivery system and demonstrated a 308% increase in peak blood levels (Cmax) and a 622% increase in area under the curve (AUC(0-10 hr)), a measure of 10-hour bioavailability
• In the same study, AUC(0-10 hr) values were 285% and 499% greater with VESIsorb CoQ10 compared to two other solubilized, bio-enhanced preparations